Cave Johnson is Sheriff.

• Professor Rafinesque of Transylvania University publishes an account of his visit to Big Bone in 1821.
• The first railroad in Kentucky opens. The horse-drawn cars run between Lexington and Louisville.

• Henry Clay wins Kentucky, but fails in his Presidential election bid against Andrew Jackson.
• The Department of Indian Affairs is established.
• The Nullification Crisis opens the debate over the issue of states' rights.
• Andrew Jackson vetoes a bill rechartering the Bank of the United States, touching off a political fight known as the Bank War.
• The Black Hawk War is fought in Illinois and present-day Wisconsin.
• The Seminole War begins.